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| "Action/Kinetics: Resembles narcotics with respect to its mechanism and analgesic effect; it is one-half to one-third as potent as codeine. Is devoid of antitussive, anti-inflammatory, or antipyretic activity. When taken in excessive doses for long periods, psychologic dependence and occasionally physical dependence and tolerance will be manifested. Peak plasma levels: hydrochloride: 2-2.5 hr; napsylate: 3-4 hr. Analgesic onset: 30-60 min. Peak analgesic effect: 2-2.5 hr. Duration: 4-6 hr. Therapeutic serum levels: 0.05-0.12 mcg/mL. t1/2, propoxyphene: 6-12 hr; norpropoxyphene: 30-36 hr. Extensive first-pass effect; metabolites are excreted in the urine."
Nurses PDR Research Center - Propoxyphene hydrochloride (Darvon)
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