Glenne Headly passed away on Thursday night, a representative of the actress told CNN.
The actress, best known for starring alongside Warren Beatty in "Dick Tracy" was 62 years old. She is survived by her husband Byron McCulloch and son Stirling.
"It is with deep sorrow that we confirm the passing of Glenne Headly," her reps said in a statement. "We ask that her family's privacy be respected in this difficult time,"
Headly, a native of Connecticut, got her start in theater and went on to star in several productions including "Extremities" alongside Susan Sarandon in 1982.
Eventually she made the transition to film and her breakout role is credited to "Dirty Rotten Scoundrels" opposite Steve Martin and Michael Caine.
She went on to star in over 25 films including "Mortal Thoughts," 'Mr. Holland's Opus" and "Sgt. Bilko."
Headly also earned two Emmy nominations for "Lonesome Dove" and "Bastard Out of California."
She was in the middle of filming the Hulu series "Future Man" alongside Josh Hutcherson and Ed Begley Jr. before her untimely death.
In 1982 she married John Malkovich and the two divorced in 1988. She then married McCulloch in 1993 and together they had a son.